Androgenetic alopecia (AGA) is also known as male-pattern baldness and is the most common cause of hair loss. Approximately 50% of men are affected by the age of 50, and thinning of the hair can begin as early as the age of 12 and as late as 45. Although the condition is benign, the psychosocial ramifications of AGA can be significant. A major determinant of AGA concerns testosterone (T), more specifically the enzymes that affect androgen metabolism. Testosterone is essential for health and well-being and it is a steroid hormone from the androgen group and is found in mammals, reptiles, birds, and other vertebrates. In mammals, T is secreted primarily by the testicles of males and ovaries of females, although small amounts are also secreted by the adrenal glands. In men, T plays a key role in the development of male reproductive tissues such as the testis and prostate as well as promoting secondary sexual characteristics such as increased muscle, bone mass, and the growth of body-hair.
The 5-α reductase isoenzymes (type I and II) convert T to dihydrotestosterone (DHT). The levels of both types of 5-α reductase are increased in the frontal-balding follicles compared with the nonbalding follicles found in the back of the head demonstrating that these isoenzymes contribute to AGA. Dihydrotestosterone levels are also increased in the balding scalp compared with the nonbalding scalp. Furthermore, women have 3–3.5 times less 5-α reductase than men, which probably accounts for why female AGA is less severe in most cases than with male AGA. Interestingly, individuals born without 5-α reductase type II do not develop AGA.
Aromatase is an enzyme that is part of the normal androgen metabolism that may have protective effects on AGA. Aromatase converts T into estradiol and estrone and thereby results in less conversion of T into DHT. Aromatase is found in much higher levels in female scalps with six times in the frontal scalp and four times in the occipital scalp than in men. This may explain why women who suffer from AGA may still be able to preserve their frontal hairline.
Androgen receptor proteins (ARP) are found in the outer-root sheaths and in the dermal- papilla cells of the scalp follicles. Androgen receptor proteins are found to be 30% higher in the frontal-balding scalp than in the nonbalding occipital follicles, while 40% lower in women than in men.
Androgen receptor proteins are responsible for the signal transduction in the hair follicle that promotes the conversion of a thick, strong terminal hair into a miniaturized, fine hair. Interestingly, ARPs have the opposite effect in the beard and moustache, promoting thicker follicles in these areas at puberty.
Hair follicles produce both thick terminal hair and fine vellus hair. Vellus hairs develop on most of the human body from childhood, regardless of sex. At puberty, vellus hairs are replaced by terminal hairs in certain areas of the body, such as the axilla, pubis, and face; and this change occurs by the influence of androgenic hormones. The differentiation between vellus and terminal hair is their size and length, i.e., the hairs that grow <0.03 mm in diameter and <1 cm in length are considered vellus, and hairs that exceed the parameters mentioned above are considered terminal hairs.
One of the hallmarks of AGA is the conversion of thick terminal hairs into miniaturized, vellus- like hairs. This process of miniaturization (i.e., shrinking of hair volume and growth length) is usually an indication that one is undergoing hair loss. The main mechanism for miniaturization relates to the shortening of the anagen phase, i.e., the hair becomes “lazy” and does not grow to its full term.
Considering countless variations in hair-loss patterns, many classification schemes exist to define types and extent of baldness. The most widely accepted standard is the Norwood or Norwood-Hamilton classification for male-pattern baldness that was based on a study of a thousand adult men with male-pattern hair loss classified by the type of hair loss and age of the onset. Some of the findings were as follows:
All patterns of male-pattern hair loss tend to progress in stages and increase in prevalence with the age of the man. However, family history of male-pattern hair loss may be helpful in estimating probabilities for your future hair loss but cannot be predictive with complete accuracy.
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